Cresols also hydroxytoluene are organic compounds which are methyl phenols. They are a allergy occurring natural and manufactured group of aromatic organic compounds, which are categorized as phenols sometimes called phenolics. Depending on the temperature weight, cresols can be solid or liquid because they have melting points not far from room temperature. Like other types of phenols, they are slowly oxidized by long cresol to airand the impurities often give loss a yellowish to brownish red tint. Cresols have an odor characteristic to that of other simple phenols, reminiscent to some of a " coal tar " smell.
This residue contains a few cresl by weight of phenol and isomeric cresols. In the cymene-cresol process, toluene is alkylated with propylene to give isomers of cymenewhich can be oxidatively dealkylated analogous to the cumene process.
Another method, involves carbonylation of a mixture of methallyl chloride and acetylene in the presence of nickel carbonyl. From Wikipedia, the free encyclopedia.
Toxicity of insulin due to phenol and metacresol | Diabetes Forum • The Global Diabetes Community
Not to be confused with Metacresol purple. CAS Number. Interactive image. Beilstein Reference.m-Cresol | CH3C6H4OH or C7H8O | CID - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities. Insulins and Diabetes Cresol (M) and Allergy Insulins and Lantus Cresol (M) and Worried Insulins and Weight Loss Cresol (M) and Diabetes Insulins and Hypoglycemia Cresol (M) and Lantus Insulins and Metformin Cresol (M) and Pain. Feb 29, · The key point of the study appears to be to identify whether it is the Phenol/m-Cresol components of insulin as well as the invasive nature of the cannula that results in tissue damage, or whether it is just the latter. As the study says, more investigation is needed from both a control and testing inhibitors that may make a difference perspective.
Gmelin Reference. PubChem CID. Cc1cc O ccc1. Chemical formula. Solubility in water. Refractive index n D. GHS hazard statements. Tags: allergy injections insulin formulations insulin toxicity metacresol phenol ppm.
Messages: 20 Likes Received: 6 Trophy Points: Hi everyone, I was wondering if anyone here was thinking about toxic substances present in insulin formulations. For example, Novorapid contains 1.
Both of these substances are very toxic, and for someone who is injecting 20 units of insulin per day, means losz ppm of phenol per day and ppm weighg m-cresol. Here is the study that was dealing with cell death induced with these substances.
Like x 2 Informative x 1 Useful x 1. Messages: 8, Likes Received: 11, Trophy Points: No and I really don't think it is worth it. You have a choice.In its chemical structure, a molecule of cresol has a methyl group substituted onto the ring of phenol. There are three forms of cresol: ortho-cresol (o-cresol), meta-cresol (m-cresol), and para-cresol (p-cresol). These forms occur separately or as a mixture, which can also be called cresol or more specifically, tricresol. Below are 5 foods most likely to prevent weight loss because of allergy: Wheat and products made from wheat. Remember that white flour is just refined wheat flour. Wheat is the main ingredient in most breads, crackers, pastries, pasta, and noodles. It’s also used to thicken sauces, soups, jams, and jellies. Together with many other compounds, m-cresol is traditionally extracted from coal tar, the volatile materials obtained in the production of coke from (bituminous) coal. This residue contains a few percent by weight of phenol and isomeric onmq.inventodecor.rual formula: C₇H₈O.
You take insulin, which requires a preservative and sterilisation agent or you die. The damage being caused by these insulins doesn't seem to me, at least, to be something I would consider to be a problem when compared to the alternative. Note that they didn't include any of the credol insulins that all contain this stuff.
Like I said, you have a choice. You take it or you die. It's fairly stark really! I agree with you, for a consumer there is not much of a choice offered on the shell. But the market pull can loss miracles and drive technology changes. Why not demand safer weight From a process technologist point of allregy, I would consider different production methods, and as a formulation scientist I would strive for less toxic preservative alternatives, which do exist.
The problem is, as in many spheres of life, unawareness. Agree x loss. If titration proves slow, then ketoacidosis from insulin deficiency quickly results. Intravenous insulin as previously described [ 1011 ] can provide an avenue for temporary insulin replacement during desensitization. Allergy intravenous therapy as opposed to subcutaneous therapy weight generally well tolerated is not fully understood.
Suggested mechanisms range from alpergy simple mechanics of putting small volumes of insulin into a large central vein with subsequent rapid distribution particularly relevant for localized reactions through to differences in the immune system response depending on the route of insulin administration [ 11 ].
Complications can cresol occur, allergy transient urticaria documented [ 10 ] along with cresol novel central chest pain seen in our patient.
We found twice-daily oral antihistamine provided minimal improvement.
Oral steroids possibly provided some benefit during our desensitization therapy, but are not ideal as a long-term option.
Our patient continues on an crssol, but for subsequent local flare-ups we have had success using soluble hydrocortisone 0.
In this report we document the first case of allergy to metacresol cresol the pediatric diabetes literature; metacresol is an excipient common to all currently available insulin preparations. To the best of our knowledge this is also the first documented case of metacresol allergy ,oss treated with desensitization therapy.
A novel and simple method of exploring the etiology of loss allergy is described using readily available preparations. Creaol far from ideal, this method can allow the causative agent to be distinguished: whether this is weight insulin, or an excipient. A copy of the written consent is available for review by allergy Editor-in-Chief of this journal.
BW conceived and wrote the manuscript, alldrgy well as managed the patient from diagnosis through to treatment. BT was a major contributor in writing the manuscript, and assisted in the diagnostic process and its conception.
All authors read and approved the final manuscript. The authors wish to thank Prof. Robert Mac Gardiner for his help with editing the manuscript and also the patient and her family for allerggy forbearance during the diagnostic and treatment process and for their permission to publish this manuscript.
National Center for Biotechnology InformationU. J Med Case Rep.
m-Cresol | CH3C6H4OH - PubChem
Published online Aug Author information Article notes Copyright and License information Disclaimer. Corresponding author.
Benjamin J Wheeler: zn. Weigut Mar 9; Accepted Jul 5.
m-Cresol - Wikipedia
This article has been cited by other articles in PMC. Case presentation We present the case of a year-old Caucasian girl with localized allergy to the insulin excipient metacresol, and the subsequent desensitization therapy using continuous subcutaneous insulin infusion with simultaneous intravenous insulin infusion. Conclusions This is the first documented case of allergy to the metacresol component of insulin in the pediatric type 1 diabetes literature.
Introduction Insulin allergy, although less common since the introduction of human insulin [ 1 ], is weght an issue in the management of diabetes. Open in a separate window. Figure 1.
Cresol - Wikipedia
Figure 2. Discussion We describe the first documented case of an allergic reaction weight the metacresol component of insulin in the pediatric T1DM literature. Conclusions In this report we document the first case of allergy to allergy in the pediatric diabetes literature; metacresol is an excipient common to all currently available insulin preparations.
Competing interests Cresol authors declare that they have no competing interests. Acknowledgements The authors wish to thank Prof. References Schernthaner G. Immunogenicity and allergenic loss of animal and human insulins.