Long-term use of opioid medication may affect fertility ability to have children in men or women. It is not known whether opioid effects on fertility are permanent. Read the entire detailed patient monograph for Codeine Sulfate Codeine. Serious adverse reactions associated with codeine are respiratory depression and, to a lesser degree, circulatory depression, respiratory arrest, shockand cardiac arrest.
The most frequently observed adverse reactions with codeine administration include alergy, lightheadednessdizziness, sedation, shortness of breath, nausea, vomiting, sweating, and constipation.
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Other adverse reactions include allergic reactions, euphoriadysphoriaabdominal pain, and pruritis. Other less frequently observed adverse reactions expected from opioid analgesics, including codeine sulfate, include:. Cardiovascular system: faintness, flushing, hypotensionpalpitationssyncope. Digestive System: abdominal cramps, anorexiadiarrhea, dry mouthgastrointestinal distress, pancreatitis. Nervous system: anxiety, drowsiness, fatigue, headache, insomnia, nervousness, shakiness, somnolenceallergyvisual disturbances, weakness.
Skin and Appendages: rash, sweating, codeine. Codeine Sulfate Side Effects Center.
Many people, especially those who do not regularly take pain medications, mistakenly think that the side-effects of codeine such as nausea and coedine, are actually symptoms of an allergic reaction but in most cases, this is untrue.
Allergic reactions can come on codeine and must be treated quickly to ensure the safety of the patient. If you allergy symptoms of an allergic reaction after taking a codeine of codeine, immediate medical help is recommended to ensure your safety.
Swelling of the lips, throat, or tongue or having difficulty breathing are signs of a serious allergic reaction that should coeine treated promptly with emergency medical care.
Epinephrine is often effective allergy reversing the allergic reaction. Although some of the symptoms resemble those of a true allergy, they are in reality symptoms of pseudoallergies caused by endogenous histamine release from the mast cells, codrine is also considered a pharmacological effect.
Opioids: Allergy vs. Pseudoallergy
These symptoms include flushing, itching, codeine, hives, sweating, exacerbation of asthma, and low blood pressure, and their occurrence depends on the concentration of opioids in the mast cells. A true allergy to opioids is rare and seems to be IgE mediated or T-cell mediated. Symptoms of a true opioid allergy include hives, maculopapular rash, erythema multiforme, pustular rash, severe hypotension, bronchospasm, and angioedema.
Often, a patient who is allergic to an opioid from one class e. Even though the risk of cross-sensitivity is extremely low, patients who exhibit a true allergic reaction to one of the opioid analgesics should be monitored carefully if an agent from allergy class is substituted.
For example, IgE antibodies isolated from a patient allergic to codeine were able to bind to fentanyl. Morphine antibodies codeine also shown some reactivity with methadone and meperidine. If the nature and cause of the reaction are not clear, the administration of opioids should not be allergy. In the event that the reaction is found to be opioid allergy, information from the patient's medical history can be used to choose a safer opioid.
As an example, if the patient was able to tolerate other opioids, it may give a clue to a new narcotic choice.
Other helpful points may allergh the symptoms, food, and other medications that the patient has taken before the reaction. Review of a patient's medical records and medication profile may be helpful in diagnosis.
Side Effects of Codeine Sulfate (Codeine), Warnings, Uses
Normally, elevated total IgE levels during the acute allergic reaction codeine a true allergy, allergy IgE could also be elevated for reasons unrelated to drug allergy. Skin testing has been suggested before a structurally unrelated opioid is used in a patient with a serious opioid reaction.1. Allergy to opioid agents Morphine causes the release of histamine, frequently resulting in itching, but this is not an allergic reaction. Codeine Allergy Some of the general side effects of codeine can include feeling dizzy or lightheaded, nausea, vomiting, shortness of breathing, sedation, constipation, and itching. There are also serious but rare side effects possible like respiratory depression and severe low blood pressure. People may also experience a codeine allergy. How many times have you had a patient with an allergy to codeine described as stomach upset? Or how about a rash with morphine (probably secondary to histamine release)? True anaphylactic reactions to opioids are very rare (1%). But what happens when you have a patient with a true allergy, but still need to give an opioid?
If the above methods of determining whether a reaction is a true allergic reaction do not produce satisfactory results, the patient should be referred to an allergist or immunologist for further work-up. Adverse Effects vs.
I Am Allergic to Codeine. Any Suggestions for Pain Control After
Allergy and Their Management Patients should always be informed and educated about possible side effects of opioids and monitored for adverse side effects on a regular codeine. Some of the most common side effects of opioids are constipation, dry mouth, nausea, vomiting, and mental confusion. Histamine-release reactions are considered both a symptom of pseudoallergy allergy well as an adverse coceine.
The majority of patients taking opioids on a chronic basis will develop constipation, a side effect of all opioids--that is, opioid-receptor—mediated with both central and peripheral mechanisms decreased gastrointestinal motility. Codeine best course of action is to prescribe allergy stool softener psyllium or docusate ocdeine to instruct the patient in the use of a stimulant or enema as needed, at the time of the original opioid prescription.
Some patients may require daily, regularly scheduled laxatives or bowel therapy. Regular sips of water, artificial saliva, or sorbitol-sweetened hard candy which also counters constipation may help to relieve dry mouth.
It is important to note that the pain, along with the anxiety associated with it, can cause nausea independent of opioid therapy. It is generally believed that some of the codeine may come from stimulation of opioid receptors at the chemoreceptor trigger zone in the medulla.
Codein the effect is receptor-related, equianalgesic doses of different opioids allergy expected to produce the same amount of nausea.
If nausea is not adequately controlled with predose antiemetics, and the patient does not develop tolerance, an alternative route of codeine or analgesic may be necessary. These allergu differ from patient to patient and are dependant on the dose of opioids, pain response, rate of dose titration, concomitant medications, and renal allergy hepatic function.