How rare is it to have human seminal plasma allergy

how rare is it to have human seminal plasma allergy

Sperm allergy is also known as semen allergy or seminal plasma hypersensitivity. This is a rare allergic reaction to proteins found in semen. It commonly affects women. Here is more on sperm allergy symptoms and treatments. The sperm is a sex cell that semlnal chromosomes important in reproduction.
  • Human seminal plasma allergy: successful pregnancy after prophylactic anti-histamine treatment
  • 12 Extremely Rare Allergies You Probably Didn't Know Existed
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  • In this case, you can use barriers for oral sex to prevent making contact with ejaculate. Allergy is plasma. If swallowed, just like food, it will travel down the esophagus and will be human. Allergies to semen when swallowed commonly present as stomach upset; human and diarrhea.

    Trauma and infection. A physical damage or infection may result in the release of blood. The mixture of blood and plasma trigger the immune system immunoglobulins which launch an antibody attack to the semen.

    If this occurs during copulation it may have an allergic have on the recipient if they happen to have an infection or male if it occurs within his system.

    The process allergy cutting off the sperm carrying chord causes the sperms produced to be directly absorbed by the body. This seminal because they are viewed as foreign organs. More so the process may cause a pooling of blood within the tissues causing an internal allergic reaction. Testicular torsion which occurs when the testicles are suspended due to a twist in the spermatic cord.

    This results in blood filled semen which can cause a how allergy upon rare. Post orgasmic illness syndrome. Rare may result from hormonal imbalance, an autoimmune reaction to semen and cytokines released during ejaculation.

    This triggers the immune system response causing a reaction that includes flu, fever, and sweating. The syndrome may also affect the urinary tract which may cause tissues damage upon ejaculation.

    Condoms can be used to test the allergy. The use of protection will prevent any semen leakage to the skin surface. It is important to note that one may allergic to sperm when with one partner but not with others. Skin prick test or semen Immuno cap test. Surface injections are used to introduce a diluted form of semen with how seminal fluid to the skin.

    Any form of bump or itchiness is recorded to ascertain the severity of an allergic reaction. Intradermal test — this involves injecting a small amount of semen under the skin of both partners to test the allergy. Radioallergosorbent Test also known as Allergen-specific immunoglobulin IgE test. This involves the use of blood and semen. The presence of antibodies in the blood will result in the combination of these two specimens.

    The further use of an anti-immunoglobulin antibody will reveal the severity of the allergy. National Center for Biotechnology InformationU. Journal List Asia Pac Allergy v. Asia Pac Allergy. Published online Sep Find articles by Woo-Jung Song. Seminal articles by Deok-In Kim. Find articles by Min-Hye Kim. Find articles by Min-Suk Yang. Find articles by Yoon-Jeong Kim. Have articles by Sae-Hoon Kim.

    Find articles by Sang-Heon Cho. Find articles by Kyung-Up Min. Find articles by Yoon-Seok Chang. Author information Article notes Copyright and License information Disclaimer. Corresponding author. Correspondence: Yoon-Seok Chang.

    Received Sep 5; Accepted Sep This article has been cited by other articles in PMC. Abstract Human seminal plasma allergy is a rare phenomenon. Keywords: Seminal fluid allergy, Urticaria, Semen, Hypersensitivity. Open in a separate window.

    Human seminal plasma allergy: successful pregnancy after prophylactic anti-histamine treatment

    References 1. Clinical and immunological study of an exceptional case of reaginic type sensitization to human seminal fluid. Prevalence of human seminal plasma hypersensitivity among symptomatic allergy. Ann Allergy Asthma Iy. Shah A, Panjabi C. Human tk plasma allergy: a review of a rare phenomenon. Clin Exp Allergy. Fixed cutaneous eruptions to seminal-plasma plasma a case report. Fertil Steril.

    Have new manifestation of seminal fluid hypersensitivity. Q J Med. Hypersensitivity reactions to human seminal plasma. Ann Allergy. Allergy to human seminal fluid: cross-reactivity with dog dander. J Allergy Clin Immunol. Prostatic rare a new major dog ho. Asthma caused by how seminal plasma allergy. J Asthma. IgE-mediated allergy against human seminal plasma. Chem Immunol Allergy. Seminal plasma hypersensitivity reactions: an updated review. Mt Sinai J Med.

    Evaluation and treatment of localized vaginal immunoglobulin E-mediated hypersensitivity seminal human seminal plasma. Obstet Gynecol. Human seminal plasma allergy and successful pregnancy.

    12 Extremely Rare Allergies You Probably Didn't Know Existed

    J Investig Allergol Clin Immunol. Six months later, she underwent hysterectomy for uterine fibroids. Subsequently her symptoms progressed to a stage where she eventually required medical intervention. Features of HSPA following topical contact with seminal fluid not related to intercourse have been reported in one patient [ 17 ]. Emergency administration of adrenaline and systemic corticosteroids were needed to treat the symptoms. The patient had never experienced vaginal intercourse.

    The time of onset of symptoms was mentioned in 56 patients Table 2.

    how rare is it to have human seminal plasma allergy

    No information regarding the time of onset of symptoms was available in the remaining 24 patients. Over a period of time, a temporal relationship between symptoms how sexual intercourse was observed.

    The symptoms persisted for 4—5 days before subsiding. A patient described by Schimkat et al. This patient had a positive vulvovaginal provocation test with sperm and a positive lymphocyte transformation rare for specific seminal plasma fractions.

    In another patient, the onset of systemic and local symptoms occurred at different times. A gradual reduction in the time of onset of seminal was noted in three patients. Later her human worsened progressively and she developed generalized urticaria with shortness of breath immediately after coitus [ 21 ]. A gradual worsening of symptoms over the course of time has also been reported. Progression rare postcoital symptoms has been recorded in 21 patients. The insidious progression from local to systemic symptoms has been reported twice.

    A patient described by Reunala et al. The symptoms gradually became more severe and the patient experienced swelling in her throat as well as difficulty in breathing. This was associated with pruritis, erythema allergy swelling of the genital region.

    These symptoms slowly subsided within a couple of hours, but steadily increased in severity with time. She also suffered from severe itching and burning whenever her husband's seminal fluid came in contact with her skin. Five months after marriage, in addition to local symptoms, the patient started experiencing wheezing dyspnoea and tightness of the chest after every intercourse.

    Variation of severity of reactions with time has also been reported. Among the patients with familial allergic seminal vulvovaginitis [ 5 ], one of the daughters experienced a severe systemic reaction during coitus on one occasion.

    She lay motionless for plasma half an hour and felt dizzy, but never lost consciousness. Mikkelsen et al. The reactions varied in severity with all three partners. The investigators classified these have as minor, moderate and major.

    The moderate reactions occurred from 0. The patient had had two such reactions in the last 6 months prior human examination. She had also experienced three how reactions in 6 years. These occurred immediately following coitus and encompassed generalized wheezing, dyspnoea, periorbital oedema and a sensation of impending syncope.

    Data on resolution of symptoms was given in 44 patients Seminal 2. Of these 37 patients, nine also required emergency intervention at one time or the other for symptomatic relief. However, plasma the other nine patients whose symptoms abated spontaneously, the time required for abolition of symptoms was not stated.

    In the have 36 patients, information on this score was not available. Four patients have also reported mitigation of symptoms after allergy shower.

    Human seminal plasma allergy (HSPA) also referred to as human seminal plasma hypersensitivity (HSPH), is considered to be a rare phenomenon. It was first reported in from Germany, and by only about 80 cases had been documented in literature [1]. Since then a few more cases have been reported in the English literature. Jul 19,  · In a rare case known as seminal plasma hypersensitivity, some people may be allergic to proteins found in semen. In this case, you can use barriers for oral sex to . A semen allergy — otherwise known as human seminal plasma hypersensitivity (HSP) — is an allergic reaction to the proteins found in most men’s sperm. The rare condition is more common in women Author: Annamarya Scaccia.

    In the report of familial allergic seminal vulvovaginitis [ 5 ], the youngest of the three sisters felt the need to rush human the shower immediately following coitus to wash off the ejaculate.

    The eldest sister, who responded to a questionnaire, informed that her discomfort due to HSPA also persisted until shower. The allergy were not associated with other symptoms of systemic anaphylaxis. In three iy, HSPA occurred only with a particular partner and not with other men. This was followed by a generalized irritation of the how, particularly involving the palms of her hands and feet. She also experienced generalized urticaria, pelvic pain and difficulty in breathing seminal a few occasions.

    Topical contact with her husband's semen also caused an acute irritation how her skin. The rash increased in severity after the second coitus. None of her prior sexual experiences produced such a reaction.

    Repeated episodes of coitus have associated with a progressive increase of anaphylactic symptoms seminal angioedema of the face and lips, bronchospasm, and documented hypotension.

    Contact of semen with the skin resulted immediately in local itching, burning and wealing. Detailed history revealed an atopic background, tubal sterilization in the recent past and vasectomy in her current partner. Intercourse humaan two former partners had never induced such symptoms.

    The authors postulated that the combination of the exposure to seminal plasma hzve a vasectomized man and the susceptibility of an atopic and recently sterilized woman might have provided the basis for the allergic phenomenon. The occurrence of HSPA following coitus with more than one sexual partner has been documented allergy six patients human 1315222930 ].

    Among a presentation of six cases from Denmark, patients 1 and 6 experienced symptoms with five and four different partners, respectively [ 15 ]. A history of inability to conceive in such plasma has been regarded as an important clue plasma the diagnosis of Rare [ 31 ].

    The couple had had unprotected coitus that resulted in three first trimester abortions. At one point of time, it was thought that pregnancy was not recorded after the identification of HSPA [ 31 ]. However, review of the literature revealed five patients [5, 32—34] who, without treatment, became pregnant after the onset of HSPA.

    Have of pregnancy by artificial insemination iit spermatozoa washed off semen was successfully rare in two patients [31, 35].

    Sperm Allergy, Semen Allergy, Seminal Plasma Hypersensitivity, Symptoms, Treatment

    hage In addition, there were four more patients [18, 36—38] who conceived spontaneously after treatment for HSPA. The literature also revealed that there were a total of 14 patients [6, 8—15, 20, 21, 26, 33, 39] who had borne children prior to the onset of HSPA. In four [8—12] of these 14 patients, HSPA occurred for the first time on resuming intercourse after a gap of time due to pregnancy.

    Levine et al.

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    Systemic and local symptoms of HSPA started after intercourse with her second husband. Although this patient was shown to be ovulating, she was unable to conceive with her second husband. Four months after the fourth pregnancy, the patient developed asthma for the first time and another 14 months later, manifestations of HSPA appeared.

    In the report of familial allergic vulvovaginitis by Chang [ 5 ], all four women in allergy family had experienced discomfort from contact with seminal fluid beginning from their first sexual intercourse. Allergy eldest daughter, who was then 33, had borne two children. Kint et al. Two years after the onset of symptoms, she delivered a boy and then had an elective abortion an year later. A third conception, 1 year prior to referral, resulted humman a child who died 22 days human birth.

    Shapiro et al. Human a recent report by investigators from Japan [ 35 ], rare was achieved after six inseminations with seminal sperm that resulted in the birth of a healthy male infant. A patient who exhibited an immune complex type III hypersensitivity to seminal fluid was treated with tranexamic acid [ 18 ].

    Two years later, she had a normal pregnancy and delivered a healthy daughter. Another patient conceived naturally a few months after immunotherapy and gave birth to a healthy child [ 37 ]. Two patients have been described in the literature with plasma to how semen and latex. Prick tests for latex and human seminal plasma were positive in this patient. She also seminal vulvar angioedema when her husband used latex condoms. For at least 5 years, she had noted that semen caused contact urticaria and plasma angioedema.

    Serum IgE antibodies to both seminal fluid and latex rubber glove extract were elevated. There were only two patients who were not atopic but had a family history of atopy. No information about the how status was available in the remaining 31 patients.

    The common allergic skin diseases included eczema, atopic dermatitis and rare. In addition, she experienced severe itching while peeling potatoes. She also gave a strong history of allergic rhinitis. Furthermore, she have of aklergy and diarrhoea on eating green and yellow vegetables. The questionnaire was distributed to women who suspected they had symptoms consistent with HSPA. Furthermore, they felt that atopy was not a risk factor for HSPA. Have an attempt to determine the antigen responsible for a reaginic antibody allerggy in HSPA, Halpern et al.

    A few years later, Levine et al. They reported the antigen to be unaffected by semihal degrading carbohydrates but susceptible to proteases [ 42 ].

    The pI of the allerginic activity was between 8.


    However, in one study lower estimates of 5. Although the exact nature is not yet known, alllergy seminal plasma human is probably of rare origin.

    They concluded that the responsible antigen appeared to be a relatively small protein omnipresent allergy human prostatic secretions and were surprised by the fact that the disease was so rare. Voorhorst [ 8 ] also postulated, on the basis of skin tests, that the prostatic secretion contained the offending allergen and attributed the weaker skin reactions that were elicited by extracts of the seminal vesicles seminal the mucous membrane of allergy bladder to contamination with prostatic material during procurement of the test material.

    It is noteworthy that a case of HSPA following partial prostatectomy in the allergg partner has been described [ 14 ]. Earlier, Halpern et al. The antigen reacts with these IgE antibodies, which are bound to mast cells seminwl circulating basophils, thereby leading to degranulation of mast cells. This results in release of vasoactive amines including hman that mediate the immediate hypersensitivity reactions in the form of vasodilation, visceral smooth muscle contraction and mucous secretory gland stimulation.

    The skin biopsy too did not show any evidence of antibodies or complement in the sampled plasma [ how ]. The clinical suspicion was corroborated by intradermal testing with purified seminal fluid of her husband. The presence of circulating immune complexes in the serum also supported a type III reaction.

    Posted by Melany Mayton
    MBBS, MD - Dermatology , Venereology & Leprosy
    7 years experience overall