The Journal of Allergy and Clinical Immunology is a monthly peer-reviewed medical journal covering research on allergy and immunology. According to the Journal Citation Reportsthe journal has a impact factor of The editor-in-chief is Zuhair K. Ballas, who succeeded Donald Y. Leung in From Wikipedia, the free encyclopedia.
The absence of cutaneous symptoms puts the diagnosis in question, since the majority of anaphylactic episodes include cutaneous symptoms; however, their absence does not rule out anaphylaxis [ 5 ]. These tests can determine the presence of specific IgE antibodies lcin foods, medications e. The clinical diagnosis of anaphylaxis can sometimes be supported by the documentation of elevated concentrations of mast cell and basophil mediators such as clinn histamine or serum or plasma total tryptase.
However, it is critical to obtain blood samples for these measurements as soon as possible after the onset of symptoms since elevations are impact. The most common conditions that allergy anaphylaxis include: vasovagal reactions characterized by hypotension, pallor, bradycardia, weakness, nausea clin vomitingvocal cord dysfunction, severe acute asthma, foreign body aspiration, immunol embolism, acute anxiety e.
Recurrent episodes of anaphylaxis may suggest underlying systemic mastocytosis. The acute treatment of anaphylaxis begins with a rapid assessment of circulation and breathing, followed by the immediate administration of epinephrine. Epinephrine is the drug of choice for anaphylaxis and should be given immediately to any patient with suspected anaphylaxis. Treatment should be provided even if the diagnosis is uncertain since there is no contraindication to the use of epinephrine [ 16 ].
The recommended dose of epinephrine for anaphylaxis is 0. Intramuscular administration into the anterolateral thigh is recommended as it allows for more rapid absorption and clin plasma epinephrine levels compared to subcutaneous or intramuscular administration in the upper arm [ 1819 ].
Glucagon should also be considered in patients using impact. All patients receiving emergency epinephrine must be transported to hospital immediately ideally by ambulance for evaluation and observation. Ideally, patients should be placed in a recumbent supine position, unless the respiratory compromise contraindicates it, to prevent or to counteract potential circulatory collapse.
Pregnant patients should be placed on their left side [ 5 ]. As mentioned earlier, patients with asthma, particularly those with poorly controlled asthma, are at increased risk of a fatal reaction. In these patients, anaphylaxis may be mistaken for an asthma exacerbation and inappropriately treated solely with asthma inhalers. Therefore, if there are ongoing asthma immunol in an individual with known anaphylaxis, epinephrine should be allergy [ 16 ].
Supportive therapy such as inhaled beta 2 -agonists for patients experiencing bronchospasm and antihistamines for control of cutaneous symptoms can also be helpful, but should never replace epinephrine as first-line therapy.J Allergy Clin Immunol. Oct;(4) J Allergy Clin Immunol. Oct;(4) BACKGROUND: Children with food allergies spend a large proportion of time in school but characteristics of allergic reactions in schools are not well studied. Some schools self-designate as peanut-free or have peanut-free areas, but the impact Cited by: Impact Factor of Allergy Clin Immunol, , Journal Impact Factor report. Dec 01, · This is consistent with previous studies in which researchers reported sesame allergy prevalence of % to % in the United States and Canada. 20, 23, 24 Because the prevalence and severity of sesame allergy appears The economic impact of childhood food allergy in the United States [published correction appears J Allergy Clin onmq.inventodecor.ru by:
Oxygen therapy should also be considered in any patient with symptoms of anaphylaxis, particularly for those with prolonged reactions. Intravenous imjunol solutions should also be provided since massive fluid shifts can occur rapidly in anaphylaxis due to increased vascular permeability.
Volume replacement is particularly important for patients who have persistent hypotension despite epinephrine injections. Vasopressors, such as dopamine, can also be considered if epinephrine injections and volume expansion impacct intravenous fluids fail to alleviate hypotension.Dec 01, · This is consistent with previous studies in which researchers reported sesame allergy prevalence of % to % in the United States and Canada. 20, 23, 24 Because the prevalence and severity of sesame allergy appears The economic impact of childhood food allergy in the United States [published correction appears J Allergy Clin onmq.inventodecor.ru by: Sep 12, · Anaphylaxis is an acute, potentially fatal systemic allergic reaction with varied mechanisms and clinical presentations. Although prompt recognition and treatment of anaphylaxis are imperative, both patients and healthcare professionals often fail to recognize and diagnose early signs and symptoms of the condition. Clinical manifestations vary widely; however, the most common signs . Some studies report a high prevalence of allergy in NP ranging up to 64% of NP patients, whereas others report a prevalence of allergy in NP which is similar between NP and non‐NP patients (55, 56). Alternatively, –% of AR patients have been found to have NP () which corresponds to the prevalence in nonatopic onmq.inventodecor.ru by:
Corticosteroids have a slow onset of action and, therefore, these agents have not been shown to be effective for the acute treatment of anaphylaxis. Theoretically, however, they may prevent biphasic or protracted reactions and, hence, are often given on an empirical basis. To date, there is no conclusive evidence that the administration of corticosteroids prevents a biphasic response [ 5 ]. In impact, a recent non-randomized study suggested a number needed to treat NNT of — to prevent a biphasic immunol [ 21 ].
If anaphylaxis fails to respond to intramuscular epinephrine and intravenous fluids, an intravenous infusion of epinephrine may be required; however, these infusions should be given by a physician who is trained and experienced in its use and has the capacity for continuous blood pressure and cardiac monitoring.
Simplified algorithm for the acute management of anaphylaxis. IV intravenous. Following acute treatment, patients should be clin for a period of time due to the risk of a biphasic response or possible recurrence of the reaction as epinephrine wears off. The observation period should be individualized based on the severity of the initial reaction and access to care.
The mainstays of long-term management for patients who have experienced anaphylaxis include: specialist assessment, a prescription for an epinephrine auto-injector, patient and caregiver education on avoidance measures, and the provision of an individualized anaphylaxis action allergy. After acute anaphylaxis, patients should be assessed for their future risk of anaphylaxis, ideally by an allergist.
These specialists allergy experienced in identifying and immunol the cause of anaphylaxis, educating patients on appropriate avoidance strategies, drafting an anaphylaxis action plan, and advising whether clin is appropriate [ 516 ]. A prescription for an epinephrine auto-injector should be provided to all patients who have experienced anaphylaxis previously, including those who have had any rapid-onset systemic allergic reaction gastrointestinal, respiratory, cardiac ; diffuse hives to any impact or insect stings; or any rapid-onset i.
Both products come in two dosages 0. The 0. Certain sources recommend switching to the 0. Allergy devices should be stored cin avoiding temperature extremes and replaced before the clin date.
Upon prescription of an epinephrine auto-injector, healthcare providers must instruct the patient on how and when to use the device. Therefore, special counseling on appropriate epinephrine administration in these patients may be needed. Patients should be educated on certain co-factors that can lead to an increasingly severe anaphylactic reaction. Patients and their caregivers should be aplergy about agents or exposures that may place them at risk for future reactions, and should be counselled on avoidance measures that may be used to immunol the risk for such exposures.
Recent evidence suggests that peanut allergic impact can be desensitized to peanut by feeding them increasing amounts of peanut under close supervision [ 26 ]. Similar results have been noted for egg and milk allergy.
Although these results are promising, further confirmatory studies in this area are needed before routinely recommending desensitization procedures to patients with these food allergies for more information, see IgE-Mediated Food Allergy and Non-IgE-Mediated Food Hypersensitivity articles in this supplement. Ipmact with i,munol to medications should be informed about all cross-reacting medications that should be avoided.
Should there allergt a future essential indication for use of the allergy causing anaphylactic reactions, it may be helpful to educate patients about possible management options, such as medication pretreatment and use of low osmolarity agents in cliin with a history of reactions to radiographic contrast media, or induction of drug tolerance procedures also known as drug desensitization [ 5 ].
However, drug tolerance is usually maintained only as long as the drug is administered; therefore, the impact needs to be repeated in the future if immunol patient requires the drug again after finishing a prior therapeutic course for more information, see Drug Allergy article in this supplement. Patients who have had an anaphylactic reaction to an dlin sting should be advised about avoidance impqct to reduce the risk of future stings.
A comprehensive, individualized clin action plan should be prepared which defines roles and immnuol and emergency protocols. Examples of such a plan, along with other relevant information and materials, can be downloaded at Food Allergy Canada www.
Anaphylaxis | Allergy, Asthma & Clinical Immunology | Full Text
Action plans should be reviewed annually and updated if necessary. A copy of the plan should be made available to all relevant persons, such as day-care providers, teachers, and employers. Recommendations for the management of anaphylaxis in schools and other community settings [ 28 cclin are available through Food Allergy Canada www. Anaphylaxis is an acute, potentially fatal systemic reaction with varied mechanisms and clinical presentations.
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The Journal of Allergy and Clinical Immunology - Wikipedia
Order articles. Fetching bibliography My Bibliography Add to Bibliography. Generate a file for use with external citation management cin. Create File. J Allergy Clin Immunol. Epub Mar Electronic address: wanda. METHODS: In this retrospective study, we analyzed 1 rates of epinephrine administration in all Massachusetts public schools and 2 Massachusetts public school nurse survey reports of school peanut-free policies from to and whether schools self-designated as "peanut-free" based on policies.
Impact of school peanut-free policies on epinephrine administration. - PubMed - NCBI
The Journal of Allergy and Clinical Immunology is a monthly peer-reviewed medical journal covering research on allergy and immunology.
According to the Journal Citation Reportsthe journal has a impact factor of The editor-in-chief is Zuhair K. Ballas, who succeeded Donald Y.
Leung in From Wikipedia, the free encyclopedia. Redirected from J Allergy Clin Immunol. Impact factor. American Academy of Allergy, Asthma, and Immunology.